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Laboratorio di Patologia molecolare
Pubblicazioni relative all’attività del gruppo1. BaryshnikovaE, DestroA, InfanteMV, CavutoS, CarboniU, AlloisioM, Ceresoli GL, LutmanR, Brambilla G, ChiesaG, RavasiG, RoncalliM. Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program. Clinical Cancer Research 14:1913-9, 2008 2. Destro A, Ceresoli GL, Baryshnikova E, Garassino I, Zucali PA, De Vincenzo F, Bianchi P, Marenghi E, Testori A, Alloisio M, Santoro A, Roncalli M. Gene methylation in pleural mesothelioma: Correlations with clinico-pathological features and patient’s follow-up. Lung Cancer 59: 369-76, 2007 3. Di Tommaso L, Franchi G, Park NY, Fiamengo B, Destro A, Morenghi E, Montorsi M, Torzilli G, Tommasini M, Terracciano L, Tornillo L, Vecchione R, Roncalli M. Diagnostic value of HSP-70, Glypican 3 and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 45: 725-34, 2007 4. Park YN, Kojiro M, Di Tommaso L, Dhillon AP, Kondo F, Nakano M, Sakamoto M, Park C, Tsui W, Bioulac-Sage P, Balabaud C, Quaglia A, Theise ND, Roncalli M. Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 109:915-23, 2007. 5. Miranda E, Destro A, Malesi A, Balladore E, Bianchi P, Baryshnikova E, Franchi G, Morenghi E, Laghi L, Gennari L, Roncalli M. Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. Br J Cancer. 95:1101-7, 2006 6. Di Gioia S, Bianchi P, Destro A, Grizzi F, Malesci A, Laghi L, Levrero M, Morabito A, Roncalli M Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. BMC Cancer 6:89, 2006 7. Destro A, Ceresoli GL, Falleni M, Zucali PA, Morenghi E, Bianchi P, Pellegrini C, Cordani N, Vaira V, Alloisio M, Rizzi A, Bosari S, Roncalli M EGFR overexpression in malignant pleural mesothelioma. An immunohistochemical and molecular study with clinico-pathological correlations. Lung Cancer 51: 207-15, 2006 8. Destro A, Bianchi P, Alloisio M, Laghi L, Di Gioia S, Malesci A, Cariboni U, Gribaudi G, Bulfamante G, Marchetti A, Bosari S, Infante G, Ravasi G, Roncalli M. k-ras and p16 alterations in sputum of NSCLC patients and in haevy asymptomatic chronic smokers. Lung Cancer, 44 :23-32; 2004 9. Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T, Oldani S, Cotichini R, Roncalli M. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 39: 208-214 ; 2003 10. Roncalli M, Bianchi P, Bruni B, Laghi L, Destro A, Gennari L, Tommasini M, Malesci A, Coggi G Methylation framework of cell cycle gene inhibitors in liver cirrhosis and associated hepatocellular carcinoma. Hepatology 36:427-432; 2002. 11. Maggioni M, Coggi G, Cassani B, Bianchi P, Romagnoli S, Mandelli A, Borzio M, Colombo PG, Roncalli M Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies. Hepatology 32:942-946, 2000 12. Roncalli M, Bianchi P, Ceva Grimaldi G, Ricci D, Laghi L, Maggioni M, Opocher E, Borzio M, Coggi G Fractional allelic loss in non-end stage cirrhosis: correlations with hepatocellular carcinoma development during follow-up. Hepatology 31: 846-850, 2000 13. Roncalli M, Roz E, Coggi G, Di Rocco M, Bossi P, Minola E,
Gambacorta M, Borzio M The vascular profile of regenerative and dysplastic nodules of the cirrhotic
liver: diagnostic and classificative implications. Hepatology 30: 1174-1178, 1999
Pubblicazioni selezionate - prof. Massimo Roncalli1. Borzio M, Bruno S, Roncalli M, Mels GC, Ramella G, Borzio F, Leandro G, Servida E, Podda M. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study. Gastroenterology 108:812-817, 1995. 2. Roncalli M, Roz E, Coggi G, Di Rocco M, Bossi P, Minola E, Gambacorta M, Borzio M The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: diagnostic and classificative implications. Hepatology 30: 1174-1178, 1999. 3. Maggioni M, Coggi G, Cassani B, Bianchi P, Romagnoli S, Mandelli A, Borzio M, Colombo PG, Roncalli M Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies. Hepatology 32:942-946, 2000. 4. Roncalli M, Bianchi P, Ceva Grimaldi G, Ricci D, Laghi L, Maggioni M, Opocher E, Borzio M, Coggi G. Fractional allelic loss in non-end stage cirrhosis: correlations with hepatocellular carcinoma development during follow-up. Hepatology 31: 846-850, 2000. 5. Fracanzani AL, Burdick L, Borzio M, Roncalli M, Bonelli N, Borzio F, Maraschi A, Fiorelli G, Fargion S. Contrast-enhanced doppler ultrasonography in the diagnosis of hepatocellular carcinoma and premalignant lesions in patients with cirrhosis. Hepatology 34:1109-12, 2001. 6. Roncalli M, Bianchi P, Bruni B, Laghi L, Destro A, Gennari L, Tommasini M, Malesci A, Coggi G. Methylation framework of cell cycle gene inhibitors in liver cirrhosis and associated hepatocellular carcinoma Hepatology 36:427-432; 2002. 7. Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T, Oldani S, Cotichini R,
Roncalli M. Impact of large regenerative, low grade and high grade dysplastic nodules in
hepatocellular carcinoma development. J Hepatol 39: 208-214, 2003.
8. Trere’ D, Borzio M, Roncalli M, Derenzini M Nucleolar hypertrophy correlates with hepatocellular carcinoma development in liver cirrhosis due to HBV infection. Hepatology 37: 72-78; 2003 . 9. Roncalli M Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience. Liver Transpl, 10: 9-15; 2004. 10. Park YN, Roncalli M. Large liver cell dysplasia: A controversial entity. J Hepatol 45:734-43, 2006. 11. Di Tommaso L, Franchi G, Park NY, Fiamengo B, Destro A, Morenghi E, Montorsi M, Torzilli G, Tommasini M, Terracciano L, Tornillo L, Vecchione R, Roncalli M. Diagnostic value of HSP-70, Glypican 3 and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 45: 725-34, 2007.
12. Park YN, Kojiro M, Di Tommaso L, Dhillon AP, Kondo F, Nakano M, Sakamoto M, Park C, Tsui
W, Bioulac-Sage P, Balabaud C, Quaglia A, Theise ND, Roncalli M. Ductular reaction is helpful in
defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer
109:915-23, 2007.
13. Plentz RR, Park YN, Lechel A, H Kim, Nellessen F, Langkopf BHE, Wilkens L, Destro A, Fiamengo B, Manns MP, Roncalli M, Rudolph KL. Telomere shortening and loss of p21-expression characterize multistep hepatocarcinogenesis in humans. Hepatology 45:968-76, 2007. 14. Bioulac-Sage P, Balabaud C, Bedossa P, Scoazec JY, Chiche L, Dhillon AP, Ferrel L, Roskems VPT, Vilgrain V, Wanless IR, Zucman-Rossi J and members of the Laennec and Elves groups. Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update. J Hepatology 46:521-7, 2007. 15. Roncalli M, Borzio M, Di Tommaso L. Hepatocellular dysplastic nodules.Hepatol Res. Suppl 2:S125-34, 2007. |